Browsing by Author "Rios Acevedo, Jhon Jairo (Director)"
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Item Caracterización de incidencias de reacciones adversas medicamentosas asociadas a anticoagulantes y diseño de guía de uso clínico para pacientes anticoagulados(Universidad Santiago de Cali, 2024) Vélez Hernández, Natalia; Rios Acevedo, Jhon Jairo (Director)Pathologies associated with poor blood coagulation such as DVT (deep vein thrombosis), stroke (cerebrovascular accident), venous thromboembolism, pulmonary embolism, among others; These require a drug that helps the clot that is produced inside a vein or artery not to occlude it, at this point is when anticoagulants play a very important role, being one of the most widely used groups of drugs in Colombia, for this reason a retrospective study was conducted by reviewing 150 clinical histories of anticoagulated patients in the health provider institution Hospital Universitario del Valle, in the period from 2018 to 2022, in order to identify what is the incidence of a patient to present or not an ADR (adverse drug reaction) or AE (adverse event). The age group between 40-90 years was identified, where the prevalence of presenting an undesired reaction during treatment varied according to the anticoagulant used: for Enoxaparin it was 74%, for Dalteparin it was 71%, for Apixaban it was 40% and for Heparin it was 89%. On the other hand, it was possible to identify that the most frequent adverse event was nausea with approximately 40%. Following this, the Chi-square test was performed, where correlation was observed between different variables such as the adverse event presented, the concentration of the anticoagulant and the duration of treatment; by means of these data, it was observed which of the hypotheses was fulfilled for each type of analysis, finding that there is no relationship of influence in terms of age vs. anticoagulant administered and age vs. frequency of presenting an undesired event, while there was a relationship between the other cases already mentioned.Item Review: Avances en la aplicación de la espectroscopia de infrarrojo cercano (NIR) en la evaluación de propiedades de alimentos cárnicos.(Universidad Santiago de Cali, 2025) Castro Buitrón, Maricel Jhohanna; Rios Acevedo, Jhon Jairo (Director)Near-infrared spectroscopy is profoundly transforming quality control in the meat industry, as demonstrated by the 56 studies analyzed in our review. The results are truly remarkable: this technology not only measures product composition with extraordinary precision (R² above 0.92), but also detects adulterations as small as 5%, verifies origin, and enables real-time process monitoring. The case studies from Spain, Argentina, and Uruguay reveal concrete achievements: reduced waste and significantly greater consistency in final products. While the challenge of heterogeneity inherent to meat tissues persists, making universal calibrations difficult, continuous advances in miniaturization, data processing, and integration with automated systems are constantly expanding its field of application, making this technology accessible even to small producers. NIR is emerging as an indispensable tool in a sector where transparency, efficiency, and quality assurance constitute increasingly decisive competitive factors, establishing new analytical standards that respond to the growing demands of both consumers and regulatory agencies.Item Review: química forense. Métodos de extracción y detección de sustancias psicoactivas en cabello y uñas"(Universidad Santiago de Cali, 2025) Silva Correa, Herlen Dallana; Rios Acevedo, Jhon Jairo (Director)The detection of psychoactive substances in keratin matrices such as hair and nails has been a challenge for forensic toxicology due to the need for accurate, sensitive and reproducible methods to identify chronic use or prolonged exposure to drugs. This review aimed to evaluate recent studies on analytical methods employed between 2020 and 2025, with emphasis on improving recovery rate, extraction time and limit of detection (LOD). A systematic review of scientific studies describing extraction and detection techniques applied to keratin matrices was performed. This included comparative analyses of methods such as solid-phase extraction, solid-phase microextraction, ultrasound-assisted extraction and new on-line strategies. Detection technologies such as LCMS/MS, HRMS, GC-MS and biosensors were also evaluated. The results showed a clear trend towards more efficient, sustainable methods with high capacity for multianalyte analysis, as chromatographic techniques coupled to mass spectrometry offered high sensitivity and specificity, while emerging technologies stood out for their speed and portability, although with limitations in sensitivity.