Browsing by Author "Rada, Ana Mercedes"
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Item Escherichia coli ST471 Producing VIM-4 Metallo-β-Lactamase in Colombia(Mary Ann Liebert Inc., 2022) Rada, Ana Mercedes; Correa, Adriana; Restrepo, Eliana; Capataz, CesarAn Escherichia coli isolate sequence-Type 471 (ST471) producing Verona integron-encoded metallo-β-lactamases (VIM)-4 was recovered from a rectal swab in a patient without travel records with osteomyelitis in Colombia. The isolate carried a class 1 integron-borne blaVIM-4 gene with a 170-bp duplication in the 3′ end of the gene, preceded by an aac(6′)-Ib gene. The genetic environment of blaVIM-4, blaCMY-2, and sul2 genes showed similarities to the backbone of pKKp4, an IncA/C-Type plasmid from a Klebsiella pneumoniae strain carrying blaVIM-4 recovered in Kuwait. This is the first report of blaVIM-4 in Enterobacterales in South America. Our results suggest that blaVIM-4 gene was found on an IncA/C-Type plasmid that could play a role in the spread of VIM-4 carbapenemase in Colombia.