Browsing by Author "Portilla, Leidy"
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Item Physicochemical Properties and In Vitro Dissolution of Orally Disintegrating Films Based on Polysaccharides: The Case of Acetaminophen(Multidisciplinary Digital Publishing Institute (MDPI), 2025-04-08) Caicedo, Carolina; Ramírez Giraldo, Natalia; Portilla, Leidy; Saldaña, Laura; González Pérez, Giovanni; Fonseca García, AbrilDue to advances in edible films based on polysaccharides that can carry an active pharmaceutical ingredient (API), these films now provide rapid and effective release upon consumption. These films provide an alternative to conventional drug delivery methods and are known as orally disintegrating films (ODFs). This study aimed to evaluate the capacity of an edible film composed of starch, chitosan, and maltodextrin to carry an API while maintaining its physicochemical and surface properties. Acetaminophen, a hydrophilic drug, was selected as the model API and incorporated into the edible film. The film achieved an API loading capacity of approximately 4.37 mg—comparable to the standard doses of certain hydrophilic drugs. Chemical analysis using vibrational spectroscopy revealed strong intermolecular interactions between the components. X-ray diffraction analysis confirmed these interactions through a decrease in crystallinity within the biopolymeric compounds, while the model API retained its structural ordering. However, water absorption values increased by approximately 90% in the edible film. Scanning electron microscopy images showed a homogeneous dispersion of the model API throughout the film, without aggregation, demonstrating that the film can effectively accommodate this drug concentration.