Browsing by Author "Perea Agredo, Valentina"
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Item Nanorecubrimientos de Ti y Ag como bactericida o bacteriostático contra Listeria monocytogenes, Bacillus cereus y Salmonella tiphy para stents gastrointestinales(Universidad Santiago de Cali, 2024) Perea Agredo, Valentina; Saltaren Garzón, Luz Rene; Bermeo Acosta, Franklin Armando (Director)Bacterial multi-resistance, which has caused around 11,000 deaths per year, as reported by the WHO, with percentages between 20-30% attributable to implant-associated infections, either due to device migration or colonization by pathogens, is also aggravated by the decrease in the synthesis of antibiotics. Therefore, it is pertinent to address this problem by applying nanotechnology as a key strategy to mitigate the shortage of antibiotics. This nanoscale technology allows the development of innovative coatings, such as Ti/Ag, which optimize antibacterial properties through the release of silver ions. This not only improves the effectiveness of treatments, but also prevents the adhesion of bacteria to medical devices, which is important for patient safety. In this research, the inhibitory effect of Ti/Ag nanocoatings with different titanium thicknesses in nm and a fixed silver thickness of 90 nm was evaluated. The compositions were Ti90-Ag90, Ti180-Ag90, Ti270-Ag90, Ti360-Ag90 and Ti810-Ag90, respectively. Thin films of pure Ti, pure Ag and the reference control, which is glass, were also evaluated to detect which thickness represents the best antibacterial activity against bacteria such as Listeria monocytogenes, Bacillus cereus and Salmonella typhi, for the creation of future gastrointestinal stents as implants. At the Universidad del Valle, the thin films were structurally characterized, confirming the presence of silver and 6 titanium. In addition, the roughness and uniformity of the coating surface were morphologically analyzed. In the laboratory of the Santiago de Cali University, the coatings were subjected to triplicate bacterial growth tests adjusted to the McFarland scale, the results obtained demonstrated that the Ti/Ag thin films with Ti thicknesses of 90 nm, 180 nm, 270 nm, 360 nm and pure silver had antibacterial activity.