Browsing by Author "Pantoja Camacho, Lady Daniela"
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Item Terapia fágica en la era de la multirresistencia bacteriana. Una revisión sistemática(Universidad Santiago de Cali, 2021) Pantoja Camacho, Lady Daniela; Martinez Martinez, Edgar Andrés; Aranaga, Carlos Andrés; Falco Restrepo, Aura DayanaAntibiotics have played an important role in the treatment of infections caused by bacteria. However, the high rates of resistance currently reported towards these drugs represent a public health problem. Bacteriophages constitute an alternative to mitigate the resistance to the use of antibiotics because they are capable of infecting and lysing bacteria in a specific way, without these processes being affected by the changes that led to the acquisition of antibiotic resistance. Therefore, bacteriophages are suitable candidates to exert biocontrol in bacteria of clinical interest. To determine whether phage therapy has been successful in the treatment of infections caused by multidrug-resistant bacteria, this systematic review of scientific literature was carried out. Using PRISMA methodology, three scientific databases were selected: Pubmed, Science Direct, and Google Scholar, from which 25 research articles and clinical cases from the last 10 years that met the inclusion criteria were included. A review of the information from each study was carried out and it was determined that most of the infections were caused by bacteria such as S. aureus, K. pneumoniae, and A. baumanii. The results indicate that the era of multi-resistance to antibiotics promoted the increase in therapy with bacteriophages in the last three years. Likewise, in 92% of the cases studied, its application was successful. Even though positive results have been obtained in the application of phage therapy, more studies related to pharmacokinetics are needed, as well as to demonstrate more safety concerning its administration, to standardize the treatment to be used according to the infection to be treated.