Browsing by Author "Pacheco, Robinson"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Biological therapy in rheumatoid arthritis: A review of adverse reactions(Asociacion Colombiana de Reumatologia, 2022-10-01) Arturo Orozco, Víctor Hugo; Burgos García, Mónica; Girón, Luz Nelly; Pacheco, RobinsonIntroduction: The relationship between adverse events and the application of biological drugs in patients with a diagnosis of rheumatoid arthritis has been documented worldwide, but with little evidence of the situation in Colombia. If adverse events and / or drug reactions with relevant clinical findings in health because of this therapeutic treatment affect the patient's quality of life and influence health indicators at the national level and system resources, it is important to assess their impact. Objectives: To determine the frequency of adverse events and / or adverse reactions related to the use of biological drugs in a cohort of patients diagnosed with rheumatoid arthritis from a national insurer, in the period from 2000 to 2019. Methodology: A descriptive, cross-sectional, and retrospective study with analytical scope was carried out in patients diagnosed with rheumatoid arthritis, on biological therapy, under a nationwide insurer, with records in their medical records from 2000 to 2019. Results: 252 clinical records of users with a rheumatoid arthritis diagnosis and biological therapy were analysed; 62.7% had at least one adverse reaction; nine drugs were evaluated in this study: Tocilizumab, Etanercept, Adalimumab, Abatacept, Certolizumab, Golimumab, Infliximab, Rituximab, and Tofacitinib. Tofacitinib was included in this study at the request of the insurer providing the information. Conclusions: Adverse reactions with biological therapy in patients with rheumatoid arthritis are frequent and were severe in 27.3%. This is a situation previously unknown in Colombia.Item Factors associated with unsuccessful treatment outcome for tuberculosis in previously treated patients in Cali, Colombia, during the period 2015-2019(Instituto Nacional de Salud, 2023-09-30) Varela, Liddy; Ortiz, Jimena; García, Pamela K.; Luna, Lucy; Fuertes Bucheli, José F.; Pacheco, RobinsonIntroduction. Tuberculosis treatment success rates remain suboptimal.Objective. To identify factors associated with unsuccessful treatment for tuberculosis in patients with a history of tuberculosis treatment.Materials and Methods. A retrospective, analytical, observational cohort study of patients readmitted to a mycobacterial program in Cali, Colombia, was conducted. Patients older than 15 years with pulmonary tuberculosis between 2015 and 2019 with a history of tuberculosis treatment were included. Patients with resistant tuberculosis were excluded.Results. Six hundred and fifty-five patients with treatment history were admitted, 60 % for inconclusive treatment and 40 % for relapse. Compared to patients readmitted for relapse (ORa= 2.34; CI=1.62-3.38), the variables that independently explained unsuccessful tuberculosis treatment at discharge were: being homeless (ORa=2.45; CI=1.54-3.89), being drug dependent (ORa=1.95; CI=1.24-3.05), having TB/HIV coinfection (ORa=1.69; CI=1.00-2.86) or diabetes (ORa=1.89; CI=1.29-2.77), and failure to comply with previous treatment due to loss to follow-up, dropout or other causes. Programmatic variables that favored treatment success were voluntary HIV test counseling (p < 0.001) and HIV test performance (p < 0.001).