Browsing by Author "Ospina Yepes, David Santiago"
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Item Detección de drogas sintéticas en aguas residuales mediante espectrometría de masas de alta resolución (HRMS): Una revisión sistemática(Universidad Santiago de Cali, 2025) Ospina Yepes, David Santiago; Ocampo Chaguendo, Denis Mauricio (Director)The objective of this systematic review was to analyze the application of high-resolution mass spectrometry (HRMS) in the detection of synthetic drugs and new psychoactive substances (NPS) in wastewater. Through an exhaustive search in international databases (Scopus, ScienceDirect, Web of Science, Springer and Taylor & Francis), 4,977 articles were initially identified, of which, after a rigorous selection process following PRISMA guidelines, 36 relevant studies were included. The results evidenced that cocaine, MDMA and amphetamines continue to be the most prevalent illicit substances detected in wastewater, although an emerging growth in the detection of synthetic cathinones such as 3-MMC and α-PVP was reported. It was observed that HRMS, through targeted, suspect and non-targeted screening strategies, allowed efficient identification of both known compounds and emerging substances. However, the lack of standardized quantitative data and the geographical concentration of studies in Europe and Oceania were highlighted as important limitations. These findings underscore the need to expand HRMS-based environmental monitoring to less studied regions and to establish more standardized analytical protocols to strengthen the epidemiological assessment of drug use globally