Browsing by Author "Nieto Ramirez, Luisa María"
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Item Estudios de la tuberculosis desde la Sucursal del Cielo(Editorial Universidad Santiago de Cali, 2020-11-28) Nieto Ramirez, Luisa María; Díaz, Gustavo; López R., David Augusto; Castillo J., Diana Andrea; Pacheco López, Robinson; Dorado C., Rosita Nohemy; Luna Miranda, Lucy del Carmen; García Moreno, Pamela Katherine; Ferro Ramos, Beatriz Eugenia; Galvis Pedraza, Maryory; Triana Vargas, Juan Camilo; Peláez Giraldo, Marly Julieth; Rengifo Portilla, Diana Katerine; Cardona Antero, Daniel Esteban; Izquierdo, Juan Sebastián; Pereira Lemos, Manuela; Rozo Anaya, Juan Carlos; Forero, Liliana; Botero Carvajal, Alejandro; Jiménez Urrego, Ángela María; Figueroa Gómez, Jorge Enrique; Jalil, Hanni; Ospina Tascón, Vivian Lissette;Item Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid(Elsevier Inc., 2019-04-17) Nieto Ramirez, Luisa María; Mehaffy, Carolina; Dobos, Karen M.Different biochemical studies looking for the effect of INH on the physiology of Mycobacterium tuberculosis (Mtb)have been conducted. Here, we present a detailed analysis, looking at the protein variation in the Mtb cell due to exposure of sub-inhibitory concentrations of INH, evaluating three different variables: cellular fraction, genetic lineage, and INH phenotypic profile. Mass spectrometry analysis demonstrated that the most significantly affected cellular fraction was the membrane and the INH resistant strains showed the highest number of proteins altered when they were exposed to INH. Raw data are available via ProteomeXchange with identifier PXD007588. © 2019 The Authors