Browsing by Author "Lozada Martinez, Ivan David"
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Item CEA-delta could be a biomarker of tumor phenotype, clinical stage, and chemotherapeutic response in rectal cancer with OCT4-positive cancer stem cells(Frontiers Media SA, 2023) Lozada Martinez, Ivan David; Bolaño Romero, Maria Paz; Lambis Anaya, Lina; Liscano, Yamil; Suarez Causado, AmilethBackground: There is very limited evidence on biomarkers for evaluating the clinical behavior and therapeutic response in rectal cancer (RC) with positive expression of cancer stem cells (CSCs). Methods: An exploratory prospective study was conducted, which included fresh samples of tumor tissue from 109 patients diagnosed with primary RC. Sociodemographic, pathological and clinical characteristics were collected from medical records and survey. The OCT4 protein was isolated using the Western Blot technique. It was calculated the ΔCEA, ΔOCT4, and ΔOCT4/GUSB values by assessing the changes before and after chemotherapy, aiming to evaluate the therapeutic response. Results: Patients had an average age of 69.9 years, with 55% (n=60) being male. Approximately 63.3% of the tumors were undifferentiated, and the most frequent staging classification was pathological stage III (n=64; 58.7%). Initial positive expression was observed in 77.1% of the patients (n=84), and the median ΔCEA was -1.03 (-3.82 - 0.84) ng/ml, with elevated levels (< -0.94 ng/ml) found in 51.4% of the subjects (n=56). Being OCT4 positive and having an elevated ΔCEA value were significantly associated with undifferentiated tumor phenotype (p=0.002), advanced tumor progression stage (p <0.001), and negative values of ΔOCT4 (p <0.001) (suggestive of poor therapeutic response) compared to those without this status.Item Meta-Research in Geriatric Surgery: Improving the Quality of Surgical Evidence for Older Persons in a Multidimensional-Scale Research Field(MDPI, 2024) Lozada Martinez, Ivan David; Hernandez Paez, David A.; Palacios Velasco, Isabela; Martinez Guevara, Darly; Liscano, YamilThe world is facing a significant demographic transition, with a substantial increase in the proportion of older persons, as well as long-lived persons (especially nonagenarians and centenarians). One of the popular beliefs is that old age is synonymous with disease and disability. However, the successful aging hypothesis suggests that those older persons with advanced chronological age who maintain their functional capacity derive from it a delay in biological aging, enhancing the quality of organic aging and regulation. Therefore, regardless of chronological age, even in cases of extreme longevity, those older adults with a successful aging phenotype and favorable functional capacity would be expected to have satisfactory post-surgical recovery with a low risk of morbidity and mortality. Currently, there is a significant gap between the availability of high-certainty surgical evidence that allows for evidence-based interventions applicable to the long-lived population—taking into account the actual conditioning factors of the health phenotype in older persons—and, above all, predictors of satisfactory post-surgical evolution. The application of meta-research to geriatric surgery emerges as a fundamental tool to address this knowledge gap and reveals opportunities and limitations that need to be resolved in the near future to establish evidence-based surgical care for older persons. The aim of this manuscript was to present a real and globally relevant scenario related to surgical care, addressing the longevity, the availability, and the quality of surgical evidence applicable to this population, and also to present variables to consider in analysis and future perspectives in research and meta-research in geriatric surgery.Item Why is it important to implement meta-research in universities and institutes with medical research activities?(Frontiers Media SA, 2025-03-18) Lozada Martinez, Ivan David; Neira Rodado, Dionicio; Martinez Guevara, Darly; Cruz Soto, Hary Salome; Sanchez Echeverry, Maria Paula; Liscano, YamilIn recent years, there has been a growing concern over questionable practices and a lack of rigor in scientific activities, particularly in health and medical sciences. Universities and research institutes are key players in the development of science, technology, and innovation. Academic institutions, whose primary mission is to generate and disseminate knowledge, bear the responsibility in many parts of the world to act as consultants and guardians of scientific integrity in health research. Then, universities and research institutes must act as guardians of the research and technological development process, utilizing methodological and operational evaluation tools to validate the rigor and quality of medical research. Meta-research is defined as the research of research itself. Some of the most important specific objectives of meta-research include the assessment of research relevance, the evaluation of evidence validity, and the exploration of scientific integrity. A significant portion of evidence in the medical and health sciences literature has been found to be redundant, misleading, or inconsistent. Although this issue is of great importance in global health, discussions about practical and tangible solutions remain fragmented and limited. The aim of this manuscript is to highlight the significance of employing meta-research within universities and research institutes as a tool to monitor scientific rigor and promote responsible practices in medical research.