Browsing by Author "Jimenez Urrego, Angela María"
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Item Psychological suppressive profile and autoantibodies variability in women living with breast cancer: A prospective cross-sectional study(2022-10) Romo González, Tania; Barranca Enríquez, Antonia; León Díaz, Rosalba; Del Callejo Canal, Enrique; Gutiérrez Ospina, Gabriel; Jimenez Urrego, Angela María; Bolaños, Cristina; Botero Carvajal, AlejandroBreast cancer (BC) is a leading cause of women's morbimortality worldwide. Unfortunately, attempts to predict women's susceptibility to developing BC well before it becomes symptomatic, based on their genetic, family, and reproductive background have proved unsatisfactory. Here we analyze the matching of personality traits and protein serum profiles to predict women's susceptibility to developing cancer. We conducted a prospective study among 150 women (aged 18–70 years), who were distributed into three groups (n ¼ 50): women without breast pathology and women diagnosed with BC or benign breast pathology. Psychological data were obtained through standardized psychological tests and serum protein samples were analyzed through semiquantitative protein immunoblotting. The matching for psychological and immunological profiles was constructed from these data using a mathematical generalized linear model. The model predicted that women who have stronger associations between high-intensity stress responses, emotional containment, and an increased number and reduced variability of serum proteins (detected by IgG autoantibodies) have the greatest susceptibility to develop BC before the disease has manifested clinically. Hence, the present study endorses the possibility of using psychological and biochemical tests in combination to increase the possibility of identifying women at risk of developing BC before the disease shows clinical manifestations. A longitudinal study must be instrumented to test the prediction ability of the instrument in real scenarios