Browsing by Author "Gubiani, Juliana R."
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Item Rearranged Terpenoids from the Marine Sponge Darwinella cf. oxeata and Its Predator, the Nudibranch Felimida grahami(Journal of Natural Products, 2017) A. Ramirez, Maria Camila; Gubiani, Juliana R.; L. Parra, Lizbeth L.; C. Santos, Mario F.; Williams, David E.; D. Ferreira, Daiane; T. Mesquita, Juliana; Tempone, Andre G.; Ferreira, Antonio G.; Padula, Vinícius; Hajdu, Eduardo; Andersen, Raymond J.; S. Berlinck, Roberto G.Marine sponges are a rich source of terpenoids with rearranged spongian carbon skeletons. Investigation of extracts from the sponge Darwinella cf. oxeata yielded four new rearranged diterpenoids, oxeatine (2) and oxeatamides H-J (3-5), as well as the known metabolites oxeatamide A (6), oxeatamide A methyl ester (7), and membranolide (1). Oxeatine (2) has a new heterocyclic skeleton, while oxeatamide J (5) has an N-methyl urea group included in a γ-lactam moiety. UPLC-QTOF analysis of the extract obtained from the mantle of the nudibranch Felimida grahami indicated the presence of 1 and 4.