Browsing by Author "Cossio Banguero, Alejandra"
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Item Determinación de la actividad antifúngica de extractos vegetales de Piper aduncum y Thevetia peruviana(Universidad Santiago de Cali, 2022) Cossio Banguero, Alejandra; Aranaga Arias, Carlos AndrésThe yeast Candida albicans is an opportunistic pathogen capable of causing serious systemic infections in immunocompromised individuals. Several studies have demonstrated the antimicrobial properties of plant extracts, due to the ability of plants to synthesize a wide variety of bioactive compounds. In this research, the antifungal activity of dichloromethanolic, methanolic and ethyl acetate extracts of Piper aduncum and Thevetia peruviana plants on the growth of C. albicans strains ATCC 14053 and ATCC 10231 was evaluated by agar dilution and broth microdilution to determine the Minimum Inhibitory Concentration (MIC) and establish whether the extracts have fungistatic or fungicidal activity. It was evidenced that the dichloromethane extract of P. aduncum was the only one to present inhibitory activity against the strains at an extract concentration of 1000 µg/mL and presented MICs that were in a range between 256->1024 µg/mL, finally, it was established that the extract presented fungistatic activity as a result of presenting a MIC:MFC (Minimum Fungicidal Concentration) ratio higher than 4. Finally, the presence of medium polarity molecules in the P. aduncum plant with inhibitory activity against C. albicans was indirectly evidenced