Browsing by Author "Bermeo Varon, Leonardo A."
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Item Parametric simulated study of High Intensity Focused Ultrasound (HIFU) for treatment of cancer(Begell House Inc., 2018-03) de los Ríos, Laura; Bermeo Varon, Leonardo A.; Coelho de Albuquerque Pereira, WagnerHigh Intensity Focused Ultrasound (HIFU) is an acoustic therapy that is having a great progress in clinical applications, especially applied in cancer treatment. Focused ultrasound may be used to generate highly localized heating to destroy tumors of bone, brain, breast, liver, pancreas, rectum, kidney, testes and prostate. In some cases without anesthesia and on an outpatient basis. This therapy requires the knowledge of several physical properties, which are not widely known, as well as other input parameters such as frequency and intensity. Those are important for a successful treatment. In this paper, a parametric simulated study is presented to determine the suitable intervals of hyperthermia for optimal performance in treatment of cancer made with high intensity focused ultrasound.Item Thermal Effect by Applying Laser Heating in Iron Oxide Nanoparticles Dissolved in Distilled Water(Springer, 2019-09-25) Bermeo Varon, Leonardo A.; Loiola, Bruna R.; da Silva Abreu, Luiz A.; Lamien, Bernard; da Silva, Nilton Pereira; da Silva, Nilton Pereira; Silva dos Santos, DilsonDue to their physical properties and biocompatibility, iron oxide nanoparticles have received particular attention in recent years for the localized hyperthermia therapy, where they are targeted to an organ, tissue or tumor and an external source is used for heating. Several physical, chemical and biological methods have been used to synthetize nanoparticles. A mechanical alloying method was used in this work to manufacture Fe2O3 nanoparticles. The size and shape of the nanoparticles were measured by scanning electron microscopy and X-ray diffraction. In this work, experiments were conducted with the nanoparticles dissolved in distilled water and heated by a laser in the near infrared range, with temperature measurements taken by an infrared camera. Numerical simulations were performed with COMSOL Multiphysics and compared to the experimental results. The numerical results agree with the measurements within the experimental uncertainties. The experimental results revealed a larger temperature increase of the sample surface for a larger concentration of nanoparticles. Hence, the Fe2O3 nanoparticles manufactured in this work behaved as a thermal agent with potential use for the hyperthermia therapy, including the treatment of cancer.