Browsing by Author "Becerra Aguirre, Nalley Alejandra"
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Item Síntesis, caracterización y evaluación antimicrobiana del ligante N-bencil(1,4-fluorbencil) ditiocarbamato coordinado a Co(III)(Universidad Santiago de Cali, 2021) Becerra Aguirre, Nalley Alejandra; D'vries Arturo, Richard Fernando (Director); Flórez López, Edwin (Director)In this research work, the synthesis and characterization of the secondary amine N-benzyl (1,4-fluorobenzyl) amine was carried out, which was obtained by the condensation of 4-fluorbenzylamine and benzaldehyde. The formation of this was verified by FIT-IR, where the main bands of a secondary amine could be evidenced. It was also characterized by mass spectrometry which confirmed the mass of the molecular ion. In the same way, the in situ synthesis of the Co (III) coordination compound and the N-benzyl (1,4-fluorobenzyl) dithiocarbamate ligand was carried out, using the aforementioned amine and CS2 as precursor. This coordination compound was characterized by different spectroscopic techniques such as: FT-IR, through which it was possible to confirm the bidentate coordination mode for the S-M-S bond, UV-Vis in solution with which it was determined that the compound is field strong, with an octahedral geometry and thermal analysis (TGA-DSC) which allowed to determine the molecular formula of the coordination compound [Co(DTC)3]•(H2O)2. Finally, microbial inhibition tests were carried out, which allowed to know the inhibition capacity of the coordination compound against bacteria of the genus Mycobacterium using the microtiter test with resarzurin. Through the test, it was possible to determine that the compound has low inhibitory activity against bacteria such as M. smegmatis.