Browsing by Author "Ararat Sandoval, Maryleysi"
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Item Batería corta de desempeño físico (SPPB) y su relación con la predisposición de lesiones musculares y articulares asociadas al gen COL1A1 e IL6 en adultos mayores de las comunas 17, 19 y 20 de la ciudad de Santiago de Cali-Colombia(Universidad Santiago de Cali, 2023) Ararat Sandoval, Maryleysi; Guevara Campo, Gabriella; Rojas Salazar, Laura Patricia; González Ruíz, Katherine (Directora)Aging leads to a series of physiological changes, influenced by lifestyle, environment and genetics, which increases the risk of morbidity and mortality in the elderly. The COL1A1 gene encodes an essential protein in connective tissues, which, when presenting a polymorphism, is associated with musculoskeletal injuries. For its part, the interleukin 6 (IL6) gene is known as a pro-inflammatory and anti-inflammatory regulator, and it has been reported that some polymorphisms such as interleukin-6 (IL6)-174C/G and IL-6 174G/C (rs1800795) have been linked to a greater predisposition to fractures and osteoporosis in postmenopausal women respectively. These alterations, in turn, are associated with a decrease in physical abilities, leading to a progressive loss of functionality and quality of life of the elderly.Item Short Physical Performance Battery (SPPB) and Its Relationship with the Predisposition to Muscle and Joint Injuries Associated with the COL1A1 and IL-6 Gene in Older Adults(MDPI, 2024) González Ruíz, Katherine; Ararat Sandoval, Maryleysi; Camayo Guevara, Shirley; Rojas Salazar, Laura; Ordoñez Mora, Leidy Tatiana; Rosero, Ilem D.Background/Objectives: Aging leads to physiological changes influenced by lifestyle, environment, and genetics, increasing the risk of morbidity and mortality in older adults. COL1A1 gene encodes an essential protein in connective tissues, which is associated with musculoskeletal lesions. The interleukin-6 (IL-6) gene is a proinflammatory and anti-inflammatory regulator and has a greater predisposition to fractures and osteoporosis reported. In turn, these alterations are associated with a decrease in physical capacity, leading to a progressive loss of functionality and quality of life in older adults. Methods: A cross-sectional study was designed to identify the relationship between physical condition as determined using the Short Physical Performance Battery (SPPB) and the predisposition parameters for muscle and joint injuries in a population of 422 older adults, active and of ≥60 years. The variables evaluated were sociodemographic data, SPPB evaluation, and COL1A1 and IL-6 gene DNA extracted by buccal scraping. Results: SPPB total score was significantly correlated with age −0.07, weight −0.02, waist circumference −0.02, and body mass index −0.05 (p < 0.005). Conclusions: Regarding genetic variables, there were no significant differences. However, lower SPPB values were observed in the GG genotype and GT of COL1A1 when compared to the CC genotype and GC of IL-6.