Banumathy D.Khalaf, Osamah IbrahimTavera Romero, Carlos AndrésRaja, P. VishnuSharma, Dilip Kumar2025-07-042025-07-042022Banumathy, D., Khalaf, O. I., Romero, C. A. T., Raja, P. V., & Sharma, D. K. (2022). Breast Calcifications and Histopathological Analysis on Tumour Detection by CNN. Computer Systems Science and Engineering, 44(1). https://doi.org/10.32604/csse.2023.02561102676192https://repositorio.usc.edu.co/handle/20.500.12421/7166The most salient argument that needs to be addressed universally is Early Breast Cancer Detection (EBCD), which helps people live longer lives. The Computer-Aided Detection (CADs)/Computer-Aided Diagnosis (CADx) system is indeed a software automation tool developed to assist the health professions in Breast Cancer Detection and Diagnosis (BCDD) and minimise mortality by the use of medical histopathological image classification in much less time. This paper purposes of examining the accuracy of the Convolutional Neural Network (CNN), which can be used to perceive breast malignancies for initial breast cancer detection to determine which strategy is efficient for the early identification of breast cell malignancies formation of masses and Breast microcalcifications on the mammogram. When we have insufficient data for a new domain that is desired to be handled by a pre-trained Convolutional Neural Network of Residual Network (ResNet50) for Breast Cancer Detection and Diagnosis, to obtain the Discriminative Localization, Convolutional Neural Network with Class Activation Map (CAM) has also been used to perform breast microcalcifications detection to find a specific class in the Histopathological image. The test results indicate that this method performed almost 225.15% better at determining the exact location of disease (Discriminative Localization) through breast microcalcifications images. ResNet50 seems to have the highest level of accuracy for images of Benign Tumour (BT)/Malignant Tumour (MT) cases at 97.11%. ResNet50’s average accuracy for pre-trained Convolutional Neural Network is 94.17%.enbreast cancer detectionclass activation mapComputer-Aided Detectioncomputer-aided diagnosisconvolutional neural networkArticle