Rada, Ana MercedesCorrea, AdrianaRestrepo, ElianaCapataz, Cesar2025-07-042025-07-042022Rada, A. M., Correa, A., Restrepo, E., & Capataz, C. (2022). Escherichia coli ST471 Producing VIM-4 Metallo-β-Lactamase in Colombia. Microbial Drug Resistance, 28(3). https://doi.org/10.1089/mdr.2021.003110766294https://repositorio.usc.edu.co/handle/20.500.12421/7169An Escherichia coli isolate sequence-Type 471 (ST471) producing Verona integron-encoded metallo-β-lactamases (VIM)-4 was recovered from a rectal swab in a patient without travel records with osteomyelitis in Colombia. The isolate carried a class 1 integron-borne blaVIM-4 gene with a 170-bp duplication in the 3′ end of the gene, preceded by an aac(6′)-Ib gene. The genetic environment of blaVIM-4, blaCMY-2, and sul2 genes showed similarities to the backbone of pKKp4, an IncA/C-Type plasmid from a Klebsiella pneumoniae strain carrying blaVIM-4 recovered in Kuwait. This is the first report of blaVIM-4 in Enterobacterales in South America. Our results suggest that blaVIM-4 gene was found on an IncA/C-Type plasmid that could play a role in the spread of VIM-4 carbapenemase in Colombia.enBlaVIM-4ColonizationEscherichia coliMetallo-β-lactamaseArticle