Mora Vargas, Jorge AndrésOrduña Ortega, JuliethCorreia Dos Santos, Maitê BernardoMetzker, GustavoGomes, Eleni De BarrosBoscolo, Maurício2020-10-232020-10-232020-02-190008-6215http://repositorio.usc.edu.co/handle/20.500.12421/4522Described are the development of a new synthetic method using ultrasonic irradiation and sodium methoxide as catalyst for a series of pyridinic sucrose esters (py-SEs), derived from transesterification of sucrose with picolinic, nicotinic and isonicotinic methyl esters. The reaction was optimized using a 32 x 2 experimental design, the reaction time, temperature and sucrose: methyl ester molar ratio being evaluated. The method proved to be efficient for obtaining monosubstituted esters (≥83%) with high methyl ester consumption (≥79%). The monosubstituted py-SEs were isolated by semipreparative HPLC, characterized by high-resolution mass spectrometry, calorimetry, vibrational spectroscopy, and 1H and 13C NMR. The py-SEs were tested against E. coli, S. aureos, and P. aeruginosa bacteria with minimum inhibitory concentration values equal or inferior to the reference drugs for both E. coli and P. aeruginosa.enAcoustic cavitationAntibacterial activityHomogeneous catalysisPyridinic methyl estersUcrose estersArticle